a 'unique' e-commerce site generally will result in failure. typical (ie 3 column) sites are used often because they work.
quoted from alistapart:
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The inexperienced or insufficiently thoughtful designer complains that too many websites use grids, too many sites use columns, too many sites are “boxy.” Efforts to avoid boxiness have been around since 1995; while occasionally successful, they have most often produced aesthetically wretched and needlessly unusable designs.
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