As far as I'm aware you can't tag content to multiple categories, and then dynamically call up that content unless you use the limited news feature. Its all built around the single menu structure. Also calling in extra blocks of content on a category by category basis isn't really feasible. Global content blocks don't cut it when you have large numbers of pages.
The news function is fine and can be hacked to provide different forms of input - but managing them in the backend is too simple.
Imagine trying to run a site like MTV.co.uk (a drupal site) on CMS Made Simple. I wouldn't like to try.