Pantone has nothing to do with vibrant colors...it's a color matching system that is universal. It's also good when working with metallics. The ink gets mixed to where if you look at it through a magnifying glass you won't see color separations like CMYK.
Anyhow...when designing a folding brochure, make sure you take into consideration that one side is going to be smaller than the other to compensate for the fold.
quantumcopy.com/html/wc.wc?QC~Goto~Brochures_templates
has some template for guidance on folds.